GIS is an exploration tool into the use of spatial reasoning methods, to identify regions at risk, due to inadequate food and water resources, which are a result of inherent environmental scarcity. The purpose of this study is to lay an evidentiary foundation to assess food security in rural area of East Azerbaijan Province. We estimate vulnerability of food availability by approximating local food supply. Food availability was estimated by determining local supply through agricultural and industrial activities. For this to happen, relevant criteria were considered for food security assessment, and GIS multi-criteria analysis was employed for producing food security maps. Based on the obtained food security map, very high and highly secure zones include 544 villages (22.15% of rural area), while 1,905 villages (57% of rural area) were classified as being in insecure zones. The results of this research are of great importance to decision makers, and, in particular, to government departments such as the Ministry of Agriculture, the Ministry of Water Resource Management, and the Ministry of Natural Resources for the East Azerbaijan Province of Iran.